3M has had aggressive growth through acquisitions. Almost all of the acquisitions add new manufacturing sites to the existing manufacturing and distribution networks. 3M is composed of 38 divisions (as of 2011) with significant independence. There are corporate experts in the different functional areas of due diligence that bring consistency regardless of the division doing the acquisition. However, since manufacturing is not centralized and is managed by each division, there is no corporate expert neither for manufacturing due diligence or supply chain.

We report the results of a search of formal relationships between accumulation data and molecular structure for some pollutant molecules (polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls) in Gold Rush, Black Beauty and Patty Green zucchini subspecies. We employed a model-based quantum-chemical approach and Linear Multiple Regression Analysis to correlate local atomic reactivity indices with accumulation capacities.

Microwave assisted synthesis of a series of 4-hydroxy-N'-(phenylcarbonyl)-2H-1,2-benzothiazine-3-carbohydrazide 1,1-dioxides from sodium saccharin is reported. Sodium o-benzosulfimide was N-alkylated with ethyl chloroacetate followed by base catalyzed ring expansion to six membered 1,2-benzothiazine through Gabriel-Coleman type rearrangement yielding ethyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide. It was later condensed with a series of benzohydrazides synthesized from various carboxylic acids to get the title compounds.

Some new Schiff-bases derived from condensation of 3-hydrazono-2-oxo-2,3-dihydroindol-1-yl)-acetic acid hydrazide (3) with benzaldehyde, p-methoxy-benzaldehyde and p-chlorobenzaldehyde have been synthesized in high yields via refluxing in EtOH in the presence of catalytic amount of acetic acid. The synthesized compounds have been characterized by elemental analysis, IR, iH-NMR and mass spectra. Cu(II), Zn(II), Mn(II) and Fe(III) complexes of the synthesized compounds were prepared and characterized by elemental analysis, conductivity measurements, IR, UV-Vis.

The esterification of salicylic acid with methanol was carried out over a series of Ce4+modified cation-exchange resins. The effect of different reaction conditions was studied on the conversion of salicylic acid, and the optimal reaction parameters were obtained. The experimental results indicated that Ce(SC^A)Olx7 was an effective catalyst for the synthesis of methyl salicylate. The conversion of salicylic acid could reach 93.3% while its selectivity was more than 99.0%. SEM-EDS and TG-DSC analysis were employed to characterize the structure and property of the catalyst.

A novel heteronuclear bis-ligand namely 5-[4-(2-carboxyphenyl carbonyl amino)-phenyl-4-carbonyl methyl amino)-8-hydroxyquinoline was synthesized and characterized. This Bis-ligand was designated as CPHQ. Co-ordination polymers of this CPHQ bis-ligand were prepared with Cu+², Co+², Ni+², Mn+² and Zn+² metal ions. All of these Co-ordination polymers and the CPHQ ligand were characterized by elemental analysis, IR, NMR spectral studies, thermogravimetry, electronic reflectance spectral studies and magnetic susceptibility measurement.

A simple, precise, rapid and accurate LC-MS compatible RP-HPLC-PDA method has been developed and validated for the estimation of Finasteride (FIN) in bulk and tablet formulations. The chromatographic separation was achieved on Phenomenex C18 column (150 mm x 4.6 mm, 5.0 µ particle size) using the mobile phase comprising 0.02% formic acid (in water): methanol in the ratio of 20:80 (v/v) at a flow rate of 1mL/min and FIN was eluted at 3.4 min. Quantification and linearity were achieved at 220 nm over the concentration range of 5-50 µg/mL and the percentage mean of assay was found to be 100.29.

Several coatings have been proposed as an alternative to replacement processes based on hexavalent chromium. Among them stand out the hybrid films. Some hybrids films, with modified composition by the addition of photoinitiators, can be cured by ultraviolet system (UV). The UV cure is the instantaneous conversion of a reactive liquid in a solid induced by radiation, starting from the polymerization and cross-linking reactions of the chemical species.

Six spectrophotometric methods for determination of eszopiclone have been developed, validated and applied for the assay of the drug in pharmaceuticals. Methods A, B, C and D are based on ion pair complexation of drug, in acidic buffers, with triphenylmethane dyes viz., Bromothymol blue(BTB), Bromophenol blue(BPB), Bromocresol green(BCG) and Bromocresol purple(BCP). The complexes are extracted into chloroform and absorbance is measured around at 415 nm as function of concentration of the drug. The stoichiometry of the complex is found 1:1 in each case.

The present study reports the development and validation of a simple, economic and sensitive HPLC method for the concurrent determination of naproxen and esomeprazole in pharmaceutical formulations. Isocratic chromatography was performed with C-18 column and mixture of phosphate buffer (pH 6.1) and acetonitrile in ratio of (40:60, v/v) at 1.5 mlmin-1. The eluents were monitored at 302 nm using UV detector. The method was isocratic in the range of 9.38 to 300 µgml-1 for naproxen and 0.5 to 16 µgml-1 for esomeprazole.